Differential associations of oral estradiol and conjugated equine estrogen with hemostatic biomarkers
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چکیده
منابع مشابه
Effect of transdermal estradiol and oral conjugated equine estrogen on C-reactive protein in retinoid-placebo trial in healthy women.
Conjugated Equine Estrogen on C-Reactive Protein in Retinoid-Placebo Trial in Healthy Women To the Editor: In their interesting study, Decensi et al1 demonstrated that oral conjugated equine estrogen caused an increase in plasma C-reactive protein (CRP), whereas transdermal estradiol (E2) did not elevate CRP levels. The Heart and Estrogen/Progestin Replacement Study (HERS) and Women’s Health In...
متن کاملThe differential association of conjugated equine estrogen and esterified estrogen with activated protein C resistance in postmenopausal women.
OBJECTIVES Clinical trials have demonstrated that oral conjugated equine estrogen (CEE) therapy with or without medroxyprogesterone (MPA) increases venous thrombotic risk but this safety issue has not been investigated for other oral estrogens. Based on observational study findings that esterified estrogen (EE) was not associated with venous thrombotic risk whereas CEE was, we hypothesized that...
متن کاملHemostatic Effects of a Novel Estradiol-Based Oral Contraceptive
BACKGROUND A novel estradiol-based combined oral contraceptive (COC) is currently available in many countries worldwide, including Europe and the US. Based on previous studies, it is expected that this estradiol-based COC will have a reduced hepatic effect compared with COCs containing ethinylestradiol with regard to proteins controlling the hemostatic balance. OBJECTIVE The aim of this study...
متن کاملOral conjugated equine estrogen increases plasma von Willebrand factor in postmenopausal women.
OBJECTIVES We sought to test whether one month of daily oral conjugated equine estrogen (CEE) or transdermal estradiol alters hemostatic factors in postmenopausal subjects. BACKGROUND Estrogen replacement therapy and hormonal replacement therapy (HRT) effect an early increase in cardiovascular events in postmenopausal women. Circulating plasma von Willebrand factor (vWF) antigen is a marker o...
متن کاملConjugated equine estrogen, esterified estrogen, prothrombotic variants, and the risk of venous thrombosis in postmenopausal women.
BACKGROUND Joint exposure to oral conjugated equine estrogen (CEE) and prothrombotic genetic variants factor II G20210A or factor V G1601A (Leiden) increase venous thrombotic risk 6- to 16-fold in postmenopausal women. Esterified estrogen (EE), an alternative estrogenic compound, appears not to be associated with increased risk and nothing is known about the joint risk with prothrombotic geneti...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2014
ISSN: 1538-7933
DOI: 10.1111/jth.12560